Primary demyelination in transgenic mice expressing interferon-γ

Antinuclear Autoantibodies and Lupus Nephritis in Transgenic Mice Expressing Interferon γ in the Epidermis

Systemic lupus erythematosus (SLE) is a potentially fatal non-organ-specific autoimmune disease that predominantly affects women. Features of the disease include inflammatory skin lesions and widespread organ damage caused by deposition of anti-dsDNA autoantibodies. The mechanism and site of production of these autoantibodies is unknown, but there is evidence that interferon (IFN) gamma plays a...

Pathogenesis of axonal dystrophy and demyelination in alphaA-crystallin-expressing transgenic mice.

We recently described a transgenic mouse strain overexpressing hamster alphaA-crystallin, a small heat shock protein, under direction of the hamster vimentin promoter. As a result myelin was degraded and axonal dystrophy in both central nervous system (especially spinal cord) and peripheral nervous system occurred. Homozygous transgenic mice developed hind limb paralysis after 8 weeks of age an...

Eosinophilia in Transgenic Mice Expressing

Experiments in vitro suggest that although interleukin 5 (IL5) stimulates the late stages ofeosinophil differentiation, other cytokines are required for the generation of eosinophil progenitor cells . In this study transgenic mice constitutively expressing the IL-5 gene were established using a genomic fragment of the 11,5 gene coupled to the dominant control region from the gene encoding human...

Transgenic Mice Expressing Different Levels

Eosinophilia in transgenic mice expressing interleukin 5

Experiments in vitro suggest that although interleukin 5 (IL-5) stimulates the late stages of eosinophil differentiation, other cytokines are required for the generation of eosinophil progenitor cells. In this study transgenic mice constitutively expressing the IL-5 gene were established using a genomic fragment of the IL-5 gene coupled to the dominant control region from the gene encoding huma...